[Frontiers in Bioscience 3, e230-237, November 1, 1998] 230 GENE THERAPY AND PANCREATIC CANCER
نویسندگان
چکیده
1. Abstract 2. Introduction 3. Molecular Biologic Targets in Pancreatic Cancer 3.1. p53 3.2. K-ras 3.3. DPC-4, p16, and Rb 3.4. Bcl-2 3.5. Others 4. Methods for Gene Transfer 4.1. Viruses 4.1.1. Retroviruses 4.1.2. Adenoviruses 4.1.3. Adeno-associated viruses 4.2. Liposomes 4.3. Naked DNA technology 5. Manipulation of Genetic Targets 5.1. Restoration of Tumor Suppressor Genes and Anti-Oncogene Strategies 5.1.1. Gene Overexpression 5.1.2. Antisense, Ribozymes, and Drug Susceptibility Genes 5.2. Immunotherapy 5.3. Bystander Effect 6. Measuring Response to Gene Therapy 6.1. Gene Expression 6.2. Apoptosis and Cell cycle Arrest 7. Current Status of Pre-clinical Gene Therapy Studies in Pancreatic Cancer 8. Perspective 9. Acknowledgments 10. References
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